Cancer Epigenetics

Epigenetics refers to the heritable change in gene expression that does not involve changes to the underlying DNA sequence. DNA methylation, histone modifications and non-coding RNAs (ncRNA) play fundamental roles in epigenetic regulation.

The study of epigenetic modifications of the Cancer cell genome that does not involve a change in the nucleotide sequence is called Cancer Epigenetics. Risk expectation, Prediction and Cancer prevention, growth counteractive actions are also promising and encouraging areas of Epigenetics. A high adequacy of demethylating agents was accounted for essentially in haematological malignancies in view of new conventions with the low dose and long exposure, and their utilization is presently being striven for strong tumors.

During the cell transformation to a cancerous cell, Epigenetic modifications are also important like genetic mutations. Their manipulation brings a promising approach for the prevention, detection, and therapy of Cancer.

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